Using Nature-Powered Supplements to Bolster the Immune Systems

Immune Modulator​ PGX-Yeast Beta Glucan (YBG)​

COSCIENS is developing a superior immune boosting supplement where the PGX technology is used to purify and dry Yeast Beta Glucan in small (less than 10 microns) particles. Researchers believe that such small Yeast Beta Glucan particles are uniquely effective because their size allows them to be easily absorbed through the Peyer’s patches in the gut, giving them direct access to the lymphatic system. Once in the lymphatic system, they can quickly enhance the immune system’s ability to detect and respond to infections more efficiently, reduce inflammation and support long-term immune resilience. Their targeted action makes them a powerful and innovative solution for improving overall immune health, offering significant potential in the growing health and wellness market.

“Microparticulate, non-aggregated (yeast) Beta Glucan is a potent immune potentiation isolate” – Kenneth Hunter, Jr. Sc.D.

“When the macrophage is activated by receptor contact with a Yeast Beta Glucan particulate, a cascade of events transforms the cells into ‘an arsenal of defense’” – Joyce Kathleen Czop, Ph.D., MBA

Potential Immune System Benefits of Yeast Beta Glucan:

Activation of Immune Cells

  • According to the US FDA, EMA and Health Canada, food products containing 3 grams (0.1 oz) of Oat Beta Glucan can reduce the risk of heart disease and reduce cholesterol. COSCIENS’ Oat Beta Glucan chewable is a nutrition bar designed to reduce the risk of heart disease. Each bar contains 1 gram of gluten free Oat Beta Glucan and is designed to be taken three times a day.

 

Digestion & Metabolic Support

  • Supports Healthy Blood Sugar Levels – Slows digestion, preventing blood sugar spikes and promoting steady energy levels.⁴
  • Promotes Gut Health – Acts as a prebiotic, feeding beneficial gut bacteria to improve digestion and microbiome balance.⁵
  • Aids in Weight Management – Increases satiety and reduces cravings by slowing gastric emptying, which can help with appetite control.⁶

 

Enhanced Phagocytic Activity

  • Improves the ability of immune cells to engulf and destroy pathogens, strengthening the body’s defense mechanisms against infections.²

 

Modulation of Cytokine Production

  • Influences the production of cytokines, which are crucial for immune signaling, thereby coordinating immune responses and reducing inflammation.³

 

Potential Clinical Benefits:

Reduction in Upper Respiratory Tract Infections

  • Clinical trials have demonstrated that supplementation with Yeast Beta Glucans can decrease the incidence of upper respiratory tract infections, enhancing overall immune health.⁴

Adjuvant in Cancer Therapy

  • Yeast Beta Glucans have been studied as potential adjuvant agents in immuno-oncology, showing promise in enhancing the effectiveness of cancer treatments.⁵

Support During Stress

  • Supplementation has been associated with improved immune markers and reduced fatigue among individuals experiencing moderate stress.⁶

Demonstrated to Be Safe and Well-Tolerated

Safe for Consumption
  • Studies indicate that oral intake of insoluble Yeast Beta Glucans is safe and effectively strengthens the immune system.⁷
Antioxidant Properties
  • Yeast Beta Glucans possess antioxidant properties, helping to combat oxidative stress and reduce inflammation, contributing to overall well-being.⁸
  1. Brown, G. D., & Gordon, S. (2001). Immune recognition. A new receptor for beta-glucans. Nature, 413(6851), 36–37. https://pmc.ncbi.nlm.nih.gov/articles/PMC10302218
  2. Vetvicka, V., Vannucci, L., Sima, P., & Richter, J. (2019). Beta-glucan: Supplement or drug? From laboratory to clinical trials. Molecules, 24(7), 1251. https://pmc.ncbi.nlm.nih.gov/articles/PMC10302218
  3. Bashir, K. M., & Choi, J. S. (2017). Clinical and physiological perspectives of β-glucans: The past, present, and future. International Journal of Molecular Sciences, 18(9), 1906. https://pmc.ncbi.nlm.nih.gov/articles/PMC10302218
  4. Graubaum, H. J., Busch, R., Stier, H., & Gruenwald, J. (2012). A double-blind, randomized, placebo-controlled nutritional study using an insoluble yeast beta-glucan to improve the immune defense system. Food & Nutrition Sciences, 3(6), 738–746. https://www.mdpi.com/2076-3417/12/10/5208
  5. Vetvicka, V., & Vetvickova, J. (2012). Combination of glucan, resveratrol and vitamin C demonstrates strong anti-tumor potential. Anticancer Research, 32(1), 81–87. https://www.explorationpub.com/Journals/etat/Article/100236
  6. Nieman, D. C., Henson, D. A., Gross, S. J., & Jenkins, D. P. (2007). Quercetin reduces illness but not immune perturbations after intensive exercise. Medicine & Science in Sports & Exercise, 39(9), 1561–1569. https://www.nature.com/articles/s41430-025-01567-4
  7. Stier, H., Ebbeskotte, V., & Gruenwald, J. (2014). Immune-modulatory effects of dietary yeast beta-1,3/1,6-D-glucan. Nutrition Journal, 13, 38. https://www.mdpi.com/2076-3417/12/10/5208
  8. Novak, M., Vetvicka, V., & Yvin, J. C. (2008). Marine beta-1,3 glucan stimulates both humoral and cellular immunity. International Journal of Biological Macromolecules, 42(1), 1–5. https://pmc.ncbi.nlm.nih.gov/articles/PMC10302218